DOTA-NHS ester is a highly effective chelating agent used in radiolabeling and bioconjugation for imaging and targeted therapy. It combines a DOTA group that tightly binds radiometals like Gallium-68, Lutetium-177, and Yttrium-90 with an NHS ester that reacts with primary amines on proteins and peptides, forming strong amide bonds.
Key Features:
- Chelating Power: DOTA forms stable complexes with radiometals, ideal for PET, SPECT, and radiotherapy.
- NHS Ester Reactivity: Easily attaches to primary amines on biomolecules, facilitating targeted conjugation.
- High Stability: Ensures robust metal-chelate formation for reliable performance in diagnostics and treatment.
Applications:
- Radiolabeling: Binds radiometals for precise imaging and therapeutic targeting in PET and radiotherapy.
- Bioconjugation: Links to antibodies, peptides, and proteins for enhanced targeted delivery in medical imaging.
- Diagnostics: Develops targeted imaging agents to detect and monitor diseases.
Benefits:
- Versatile: Conjugates easily to various biomolecules, broadening its use across medical and research fields.
- Reliable: Provides strong, stable metal complexes, crucial for effective imaging and therapy.
- Targeted Precision: Supports the precise localization of radiolabeled agents, improving diagnostic and therapeutic accuracy.
Storage and Handling:
- Store at -20°C in a dry, inert environment.
- Handle using standard precautions for reactive chemicals.
DOTA-NHS ester is essential in nuclear medicine and oncology, offering reliable and precise solutions for advanced imaging and targeted therapies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
