DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine), CAS:4004-05-1, also known as 1,2-DOPE and DOPE lipid. it is a synthetic version of a naturally occurring phospholipid called phosphatidylethanolamine (PE). It contains 18:1 fatty acids at both the sn-1 and sn-2 positions, making it flexible and valuable for various biological applications.
Key Features:
- Synthetic Analog of PE: DOPE mimics natural PE, making it useful in studies related to cell membranes and lipid-based delivery systems.
- Emulsifier: It acts as an emulsifier to help DNA-liposome complexes cross cell membranes, which is important in gene therapy.
- Inverted Hexagonal (HII) Phase: DOPE’s ability to form this phase aids in membrane fusion, making it effective for delivering materials into cells.
Applications:
- Gene Delivery: DOPE is often paired with cationic phospholipids to boost the efficiency of non-viral gene transfection. It helps form DNA-liposome complexes, allowing DNA to enter cells for therapeutic purposes.
- Liposome Formation: DOPE is a key component in liposome-based drug delivery, stabilizing liposomes and improving the delivery of encapsulated drugs.
- Vaccine and Gene Therapy: DOPE is used in liposome formulations for delivering DNA or RNA in vaccines and gene therapy, ensuring stable and efficient delivery.
Its role in non-viral gene delivery and its emulsifying properties make DOPE essential in biotechnology and drug delivery, especially for gene transfection and membrane studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
