DMT-dG(ib) Phosphoramidite (CAS: 93183-15-4): Overview and Applications
DMT-dG(ib) Phosphoramidite (CAS: 93183-15-4) is a modified nucleotide used in the synthesis of oligonucleotides. It features a dimethoxytrityl (DMT) protective group and an isobutyl (ib) modification on deoxyguanosine (dG), enhancing the stability and incorporation efficiency of DNA sequences.
Key Features:
- DMT Group: Protects the 5′ hydroxyl group, allowing for selective coupling during oligonucleotide synthesis.
- Isobutyl Modification: Increases hydrophobicity and improves solubility, facilitating efficient incorporation into DNA strands.
Applications:
- Oligonucleotide Synthesis: Ideal for creating stable DNA sequences with modified bases.
- Gene Expression Studies: Used in probes and primers for analyzing gene regulation and expression.
- Antisense Oligonucleotides: Enhances stability for therapeutic applications targeting specific RNA or DNA.
- Diagnostics: Supports the development of DNA-based diagnostic assays.
DMT-dG(ib) Phosphoramidite is essential for synthesizing modified oligonucleotides in research, diagnostics, and therapeutic development.
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