DMT-2′-Fluoro-dG(Ib) Phosphoramidite, also known as DMT-2′-Fluoro-dG(Ib) Amidite (CAS 144089-97-4), is a fluorine-modified deoxyguanosine phosphoramidite. This phosphoramidite contains a 2′-fluoro modification and an isobutyryl (Ib) protecting group, allowing precise incorporation of guanine into DNA oligonucleotides during solid-phase synthesis. The 2′-fluoro modification enhances oligonucleotide stability, making the resulting sequences more resistant to enzymatic degradation.
Key Features:
- CAS Number: 144089-97-4
- Other Names: DMT-2′-Fluoro-dG(Ib) Amidite
- Chemical Structure: Fluorine-modified deoxyguanosine with isobutyryl protection
- Function: Building block for synthesizing fluorinated DNA oligonucleotides
- Protection Groups: Isobutyryl protects guanosine’s exocyclic amine, DMT for 5′ hydroxyl
- Applications:
- Enhances oligonucleotide stability for therapeutic and diagnostic use
- Ideal for solid-phase synthesis of DNA in genetic research and drug development
DMT-2′-Fluoro-dG(Ib) Phosphoramidite ensures controlled and stable guanine incorporation into DNA sequences, supporting advanced genetic research and therapeutic innovations.
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