DLPE-PEG-Mal, MW 3.4K polymer is a copolymer of dihydrolipoic acid (DLPE), polyethylene glycol (PEG), and maleimide (Mal). The functional groups of this polymer include a thiol group from DLPE, a hydrophilic PEG chain, and a reactive maleimide group.
The thiol group present in DLPE-PEG-Mal, MW 3.4K can undergo thiol-maleimide coupling reactions with other biomolecules that have a free thiol group, such as cysteine residues in proteins. This allows for the creation of bioconjugates that have improved stability, pharmacokinetics, and biodistribution properties.
The hydrophilic PEG chain present in DLPE-PEG-Mal, MW 3.4K increases the water solubility of the polymer, thereby enhancing its bioavailability. The PEG chain also decreases the immunogenicity of the polymer, making it a suitable candidate for drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.