DBCO-SS-aldehyde is a cleavable linker for bioconjugation. It has a DBCO group for copper-free click chemistry with azides, an aldehyde group that binds with hydrazine or aminooxy groups, and a disulfide bond for controlled release under reducing conditions.
Key Features:
- DBCO Group: Enables copper-free click reactions with azides.
- Aldehyde Group: Reacts with hydrazine or aminooxy groups for stable linkage.
- Disulfide Bond (SS): Allows for cleavage under reducing conditions.
Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted therapy.
- Protein and Peptide Conjugation: Attaches proteins or peptides to other molecules.
- Surface Functionalization: Adds functional groups to surfaces for biosensor development.
Store at -20°C and dissolve in DCM, THF, acetonitrile, DMF, or DMSO before use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
