DBCO-PEG4-propionic EVCit-PAB is a cleavable PEG-based linker commonly used in antibody-drug conjugates (ADCs). It features a DBCO group for copper-free click reactions, a Val-Cit dipeptide for enzyme-triggered cleavage, and a PAB spacer for controlled drug release. The PEG4 spacer improves water solubility and reduces steric hindrance during bioconjugation.
Key Features:
- DBCO Group: Supports copper-free click chemistry by reacting with azide-functionalized molecules.
- Val-Cit-PAB Linker: The Val-Cit dipeptide cleaves in the presence of cathepsin B, enabling selective drug release in tumor cells.
- PEG4 Spacer: Enhances solubility and flexibility, minimizing steric hindrance and improving pharmacokinetics.
Applications:
- Antibody-Drug Conjugates (ADCs): Attaches cytotoxic drugs to antibodies for targeted cancer therapy.
- Bioconjugation: Links biomolecules with built-in cleavage for controlled drug release in research and therapy.
How to Use:
- Storage: Keep at -20°C, protected from light and moisture.
- Solubility: Dissolves in organic solvents like DMSO or DMF for efficient conjugation.
DBCO-PEG4-propionic EVCit-PAB is ideal for researchers developing targeted therapeutics and drug delivery systems that require controlled and precise drug release.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
