DBCO-PEG4-PFP ester
This product is a bifunctional linker containing a dibenzocyclooctyne (DBCO) group and a pentafluorophenyl (PFP) ester separated by a PEG4 spacer. It specifically enables copper-free click chemistry with azides and efficient amine coupling for versatile bioconjugation.
Key Features and Benefits
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Dual Reactivity: DBCO for copper-free click with azides, PFP ester for amine coupling.
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PEG4 Spacer: Enhances solubility, flexibility, and reduces steric hindrance.
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High Efficiency: PFP ester reacts readily with primary and secondary amines.
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Bioorthogonal Compatibility: SPAAC click chemistry operates without copper catalysts.
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High Purity: Reliable for sensitive bioconjugation and synthesis workflows.
Applications
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Bioconjugation: Dual functional groups allow linking of azide- and amine-modified biomolecules.
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Drug Delivery: Supports construction of targeted therapeutic conjugates.
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Diagnostics: Enables immobilization and labeling of biomolecules.
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Material Science: Functionalizes surfaces and polymers with high precision.
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Multifunctional Conjugates: Facilitates orthogonal linker strategies in advanced research.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product combines bioorthogonal DBCO reactivity with amine-reactive PFP ester functionality, specifically connected through a PEG4 spacer, to deliver efficient, high-purity conjugation for chemical biology and pharmaceutical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
