DBCO-PEG2-NH-Boc
This product is a heterobifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group and a Boc-protected amine, separated by a PEG2 spacer. It specifically enables copper-free click chemistry with azides and controlled amine deprotection for sequential conjugation.
Key Features and Benefits
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Dual Functional Groups: DBCO for copper-free click chemistry; Boc-protected amine for controlled release and further conjugation.
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PEG2 Spacer: Enhances solubility while providing compact flexibility.
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Bioorthogonal Reactivity: DBCO reacts rapidly with azides under physiological conditions without copper catalysts.
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Orthogonal Strategy: Boc-protected amine allows stepwise conjugation with precision.
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High Purity: Ensures reproducibility and reliability in bioconjugation workflows.
Applications
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Bioconjugation: Couples azide-modified biomolecules with selective click chemistry.
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Sequential Conjugation: Boc-protected amine provides orthogonal reactivity for controlled release.
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Drug Delivery: Supports construction of multifunctional drug conjugates.
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Diagnostics: Functionalizes biomolecules for probe development and imaging.
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Organic Synthesis: Serves as a versatile intermediate for advanced linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates a DBCO click handle with a Boc-protected amine across a PEG2 spacer, specifically enabling copper-free bioorthogonal conjugation with precise stepwise functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
