DBCO-CONH-S-S-COONHS Ester or DBCO-CONH-S-S-NHS ester, (CAS: 1435934-53-4) is a cleavable heterobifunctional linker commonly used in bioconjugation and click chemistry. It features a DBCO group for strain-promoted azide-alkyne cycloaddition (SPAAC) and an NHS ester for coupling to primary amines. Its disulfide bond enables controlled cleavage under reductive conditions, making it ideal for targeted drug delivery and molecular assembly.
Key Features:
- Functional Groups: DBCO for copper-free click chemistry, NHS ester for amine-reactive coupling, and a cleavable disulfide bond.
- Molecular Formula: C₂₈H₂₇N₃O₆S₂
- Molecular Weight: 565.66 g/mol
- Purity: Typically ≥95%
Applications:
- Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies.
- Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions.
- Protein Labeling: Facilitates protein labeling with various probes or tags.
- Click Chemistry Reactions: Supports SPAAC without requiring a copper catalyst.
- Targeted Drug Delivery: Allows for controlled release due to its cleavable disulfide bond.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
