DBCO-C2-alcohol
This product is a compact heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group, a short two-carbon (C2) spacer, and a terminal hydroxyl group. The DBCO moiety enables rapid, copper-free SPAAC click chemistry with azides, while the hydroxyl group serves as a versatile handle for further derivatization. Its compact design provides minimal added length, making it especially useful where steric constraints are critical.
Key Features and Benefits
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DBCO Group: Performs ultrafast, copper-free click chemistry with azides.
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Hydroxyl Group: Serves as a modifiable handle for further functionalization.
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C2 Spacer: Provides compact spacing for efficient molecular incorporation.
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Versatile Reactivity: Supports orthogonal modification strategies.
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High Purity: Produced to ≥95% purity for consistent performance.
Applications
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Bioconjugation: Links azide-containing biomolecules through copper-free click chemistry.
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Probe Development: Builds compact clickable probes for imaging and diagnostics.
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Drug Delivery: Serves as a bioorthogonal linker in therapeutic conjugates.
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Organic Synthesis: Functions as a precursor for advanced PEG or alkyl linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; avoid prolonged exposure to aqueous buffers.
This product combines efficient click reactivity with a modifiable hydroxyl handle in a minimal scaffold, making it especially ideal for compact bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
