Cbz-N-Amido-PEG5-CH2COOH CAS:1449390-66-2 is a high-purity, linear polyethylene glycol (PEG) derivative featuring two distinct functional groups: the carboxybenzyl (Cbz) group and the carboxylic acid (COOH) group. This PEGylation reagent offers remarkable versatility in pharmaceutical research and development.
The Cbz group imparts stability and offers convenient protection for amine groups, enabling selective PEGylation of target molecules. The carboxylic acid group, on the other hand, allows for straightforward conjugation to amine-bearing biomolecules through amide bond formation. The hydrophilic PEG5 spacer enhances solubility, biocompatibility, and circulation time of the conjugated biomolecules.
Cbz-N-Amido-PEG5-CH2COOH is widely employed in the development of drug delivery systems, bioconjugation of therapeutic proteins, peptides, and antibodies, as well as in the synthesis of prodrugs and hydrogel-based drug formulations.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
