Cbz-N-Amido-PEG5-acid
Cbz-N-Amido-PEG5-acid is a high-purity heterobifunctional PEG linker with a carbobenzyloxy (Cbz)-protected amine and a terminal carboxylic acid for conjugation. The PEG5 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The Cbz group allows orthogonal synthesis strategies by keeping the amine protected until selective deprotection is desired.
Key Features and Benefits
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Cbz-Protected Amine: Stable under a wide range of conditions; removable by catalytic hydrogenation to reveal a free amine for further coupling.
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Carboxylic Acid: Ready for amide bond formation via carbodiimide or active ester chemistry.
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PEG5 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports sequential, orthogonal modification strategies.
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High Purity: Supplied at >95% purity for consistent and reproducible results.
Applications
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Stepwise Bioconjugation: Protect amines until the desired stage of synthesis.
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Peptide and Protein Modification: Enable site-specific amine introduction after Cbz removal.
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Nanoparticle and Surface Functionalization: Attach PEG chains with latent amine functionality.
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Drug Delivery Systems: Incorporate controlled amine activation in payload delivery strategies.
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Diagnostic and Imaging Probes: Facilitate sequential labeling with controlled reactivity.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure to maintain reactivity.
Cbz-N-Amido-PEG5-acid combines a Cbz-protected amine with a reactive carboxylic acid in a hydrophilic PEG5 framework, offering versatility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
