Cbz-N-Amido-PEG2-CH2COOH CAS:165454-06-8 is a high-quality, bifunctional PEGylation reagent/Peg Linker. It features a Cbz-protected amine group (benzyloxycarbonyl) at one terminus and a carboxylic acid group (COOH) at the other, enabling selective conjugation and controlled PEGylation of target molecules.
The Cbz group offers temporary protection of the amine group, allowing for orthogonal conjugation strategies in multi-step synthesis. Upon removal of the Cbz group under mild acidic conditions, the liberated amine functionality can be utilized for further conjugation.
In pharmaceutical research and development, Cbz-N-Amido-PEG2-CH2COOH is widely employed to enhance the pharmacokinetic properties of biologically active molecules. PEGylation using this reagent has been shown to increase solubility, reduce immunogenicity, and extend half-life, ultimately improving therapeutic efficacy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
