CBZ-aminooxy-PEG8-acid
This product is a protected aminooxy-functionalized PEG linker featuring a CBZ (carbobenzyloxy) protecting group, an eight-unit PEG spacer, and a terminal carboxylic acid. The CBZ group protects the aminooxy functionality until deprotection, while the PEG8 spacer provides excellent solubility and flexibility. The terminal acid allows further conjugation, making this reagent especially versatile for bioconjugation and synthetic applications.
Key Features and Benefits
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CBZ-Protected Aminooxy Group: Provides stability during synthesis and can be deprotected for oxime ligation with aldehydes/ketones.
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PEG8 Spacer: Enhances solubility, reduces steric hindrance, and improves accessibility in conjugation.
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Carboxylic Acid Terminus: Allows amide bond formation with amines for versatile coupling strategies.
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Orthogonal Reactivity: Combines oxime ligation (post-deprotection) with standard amide chemistry.
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High Purity: Produced to ≥95% purity for reliable and reproducible use.
Applications
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Bioconjugation: Couples biomolecules via oxime ligation after deprotection or through amide bond formation.
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Probe Development: Builds multifunctional probes for chemical biology and diagnostics.
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Drug Delivery: Serves as a linker for PEGylated therapeutics and nanocarrier design.
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Organic Synthesis: Provides a flexible intermediate for dual-reactive PEG-based reagents.
Storage and Handling
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Storage: Store at –20 °C in a dry, sealed container, protected from light and moisture.
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Handling: Use under inert conditions when possible; deprotect CBZ under standard hydrogenolysis conditions before oxime coupling.
This product integrates a CBZ-protected aminooxy group, a PEG8 chain, and a carboxylic acid terminus, making it an especially versatile tool for controlled bioconjugation, PEGylation, and multifunctional probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.