Bromoacetamide-PEG2-Boc-Amine
This product is a heterobifunctional PEG linker featuring a thiol-reactive bromoacetamide group and a Boc-protected amine for orthogonal synthesis. The PEG2 spacer provides solubility and flexibility, making it especially useful for stepwise bioconjugation, probe development, and drug delivery applications.
Key Features and Benefits:
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Bromoacetamide Group: Selectively reacts with thiols to form stable thioether linkages.
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Boc-Protected Amine: Acid-labile protection enables orthogonal synthetic strategies.
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PEG2 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Supports thiol-targeted and amine-protected workflows.
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High Purity: Ensures reproducibility in advanced conjugation.
Applications:
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Bioconjugation: Couples thiol-containing biomolecules while preserving amine protection.
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Probe Development: Builds multifunctional probes with controlled deprotection.
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Drug Delivery: Provides PEGylated scaffolds with reactive and protected handles.
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Synthetic Chemistry: Serves as a versatile intermediate in orthogonal synthesis.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of the bromoacetamide.
This product combines thiol reactivity with Boc-protected amine functionality in a PEG2 scaffold, specifically offering orthogonal chemistry and solubility for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
