Boc-amino-PEG3-SSPy, or BocNH-PEG3-SSPy, is a cleavable linker ideal for bioconjugation, especially in ADCs. It includes a Boc-protected amine to prevent unwanted reactions, a PEG3 spacer to improve solubility and flexibility, and an SSPy group for thiol binding through disulfide bonds, which can be cleaved under reducing conditions.
Key Components:
- Boc-Protected Amine: Safeguards the amine function during reactions.
- PEG3 Spacer: Enhances solubility and reduces steric hindrance.
- SSPy Moiety: Binds to thiol groups for cleavable disulfide linkage.
Applications:
- Antibody-Drug Conjugates (ADCs): Links cytotoxic drugs to antibodies for targeted therapy.
- Protein Modification: Attaches functional groups to proteins for research.
- Surface Functionalization: Adds specific functions to surfaces for biosensors and tissue engineering.
Store Boc-amino-PEG3-SSPy at -20°C, and dissolve it in DCM, THF, acetonitrile, DMF, or DMSO before use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
