TCO-PEG2-TCO
This product is a high-purity homobifunctional PEG linker with two trans-cyclooctene (TCO) groups for rapid, catalyst-free bioorthogonal tetrazine ligation. The PEG2 spacer specifically improves solubility, flexibility, and reduces steric hindrance, enabling fast and efficient conjugation in aqueous and organic systems.
Key Features and Benefits
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Dual TCO Groups – React rapidly with tetrazine-containing molecules for inverse-electron-demand Diels–Alder (IEDDA) ligation.
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PEG2 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Fast Kinetics – Enables ultrafast bioorthogonal reactions without catalysts.
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High Purity – Supplied at >95% purity for reproducible performance.
Applications
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Homobifunctional linker for biomolecule crosslinking
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Tetrazine-mediated imaging probe synthesis
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Polymer and hydrogel modification
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Site-specific labeling in live cells or organisms
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged light exposure to maintain TCO reactivity
TCO-PEG2-TCO is a high-purity linker with two TCO groups for ultrafast tetrazine ligation, connected by PEG2 for solubility and flexibility, especially ideal for catalyst-free bioorthogonal conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
