Bromo-PEG6-bromide (CAS Number: 72713-23-6) is a polyethylene glycol (PEG) derivative featuring bromide groups at both ends. These bromide groups serve as excellent leaving groups in nucleophilic substitution reactions, facilitating the incorporation of PEG spacers into various molecules. The hydrophilic PEG6 spacer enhances solubility in aqueous media, making it valuable in pharmaceutical research and development.
Chemical Properties:
- Chemical Formula: C₁₄H₂₈Br₂O₆
- Molecular Weight: 452.18 g/mol
- Physical State: Liquid
- Purity: Typically ≥95%
Applications:
- Bioconjugation and Crosslinking: Bifunctional bromide groups enable efficient nucleophilic substitution reactions for attaching PEG chains to biomolecules, improving solubility and stability.
- PROTAC Synthesis: Used as a linker in creating Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
- Nanoparticle and Surface Modification: Enhances biocompatibility and functionality of nanoparticles and surfaces for drug delivery and diagnostic systems.
Storage and Handling:
- Storage Conditions: Store at -20°C to maintain stability.
- Safety Measures: Handle with protective equipment and refer to the Safety Data Sheet (SDS) for detailed precautions.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
