Axispharm offers you high-purity Bis-sulfone-PEG4-TCO, a bis-alkylated labeling reagent that is selective for cysteine sulfur atoms from natural disulfides. These reagents are bisalkylated to conjugate two thiols derived from the two cysteine residues of the reduced native disulfide bond. This reaction results in the covalent re-bridging of disulfide bonds through three-carbon bridges, leaving the protein structurally intact. TCO enables fast click chemistry under mild conditions. Hydrophilic PEG spacers increase solubility in aqueous media.
Bis-sulfone-PEG4-TCO is a type of polyether sulfone (PES) copolymer that contains two sulfone groups and four polyethylene glycol (PEG) monomers along with a terminal carboxylic acid (TCO) group. It is a water-soluble material that is commonly used in biomedical and industrial applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.