Biotin-PEG4-S-S-NHS CAS:1260247-51-5 is a versatile, water-soluble bioconjugate that features a biotin moiety, a cleavable disulfide bond (S-S), and an N-hydroxysuccinimide (NHS) ester. The biotin enables high-affinity binding to streptavidin, the PEG4 spacer improves solubility and reduces steric hindrance, while the disulfide bond allows for controlled release, and the NHS ester reacts with primary amines to form stable amide linkages.
This bioconjugate is widely utilized in pharmaceutical research and development for targeted drug delivery, biotherapeutic modification, and diagnostic assay development. Its unique properties enable site-specific conjugation to proteins, antibodies, or other biomolecules, enhancing their pharmacokinetics, stability, and efficacy. Furthermore, the cleavable disulfide bond allows for triggered release of payloads in the reducing environment of cells, making it a valuable tool for designing smart, responsive therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
