BCN-PEG1-Br CAS:2740005-14-3 is a powerful and versatile reagent that finds wide application in drug research and development. The reagent contains a BCN group, which can react with azide-functionalized molecules in a highly specific and efficient bioorthogonal “click” reaction. The reagent also contains a PEG linker, which can improve the solubility and biocompatibility of the modified molecules, and a bromide leaving group, which enhances the efficiency of the reaction.
The BCN group is an alkene with a strained cyclooctene ring structure that reacts rapidly and selectively with azide-functionalized molecules. The resulting product is a stable triazole linkage that is highly biocompatible and can be used for the site-specific modification of a variety of molecules.
The PEG linker is a flexible, hydrophilic chain that can improve the pharmacokinetic properties of the modified molecules. It can increase the solubility of the modified molecules in water, reduce their clearance by the kidneys, and improve their circulation time in the bloodstream. Additionally, the PEG linker can act as a spacer, reducing steric hindrance between the BCN group and the modified molecule and improving the accessibility of the BCN group for the azide-functionalized molecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
![(Z,1R,8S,9r)-bicyclo[6.1.0]non-4-ene-9-methanol](https://e1752fbe.rocketcdn.me/wp-content/uploads/AP12382-CAS-1312010-01-7-1-e1691722839344.png)
