Azidoethyl-SS-propionic NHS Ester
This high-purity heterobifunctional linker features an azide for CuAAC or SPAAC click chemistry and an NHS ester for efficient amine coupling. The cleavable disulfide (SS) bond allows reductive cleavage under mild conditions for controlled release. The design is especially well-suited for reversible bioconjugation, targeted delivery, and crosslinking applications.
Key Features and Benefits
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Azide Group – Enables copper-catalyzed or strain-promoted click chemistry for rapid, bioorthogonal conjugation.
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NHS Ester – Provides efficient, selective coupling to primary amines under mild conditions.
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Cleavable Disulfide Bond – Allows controlled release of linked molecules via reductive cleavage.
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Versatility – Supports reversible linkage strategies in drug delivery, imaging, and biomolecular assembly.
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High Purity – Supplied at >95% purity for reproducible, high-performance applications.
Applications
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Reversible bioconjugation of proteins, peptides, and antibodies
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Targeted drug delivery systems
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Controlled-release crosslinking
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Multifunctional imaging and diagnostic probes
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents (e.g., DMSO, DMF); avoid prolonged exposure to moisture to preserve reactivity
This product combines click chemistry, efficient amine coupling, and a cleavable disulfide for reversible, controlled-release bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
