Azidoethyl-SS-ethylazide
This high-purity bifunctional linker features two terminal azide groups connected by a cleavable disulfide (SS) bond where the azides enable copper-catalyzed or strain-promoted alkyne–azide cycloaddition (CuAAC or SPAAC) click chemistry, while the disulfide linkage undergoes reductive cleavage under mild conditions to release linked molecules. This design is particularly suited for reversible bioconjugation, crosslinking, and targeted delivery applications especially where controlled release is essential.
Key Features and Benefits
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Dual Azide Groups – Facilitate CuAAC or SPAAC click chemistry for efficient and selective conjugation.
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Cleavable Disulfide Bond – Allows controlled release through reduction, enabling reversible linking strategies.
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Versatile Conjugation – Suitable for functionalizing biomolecules, surfaces, and nanocarriers.
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Mild Reaction Conditions – Compatible with aqueous and organic systems without harsh reagents.
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High Purity – Supplied at >95% purity to ensure reproducibility and optimal performance.
Applications
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Reversible bioconjugation and crosslinking
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Targeted drug delivery with triggered release
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Protein–protein or protein–ligand crosslinking
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Nanoparticle surface functionalization
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Smart biomaterials for diagnostics and therapeutics
Storage and Handling
- Storage: Store at –20 °C in a dry, dark place.
- Handling: Use under anhydrous conditions; avoid prolonged exposure to moisture and light to maintain reactivity.
This product is a high-purity, reversible linker with dual azide groups for click chemistry and a disulfide bond for controlled release, especially ideal for advanced bioconjugation and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
