Azidoethyl-PEG2-t-Butyl ester
This product is a heterobifunctional PEG2 linker with a terminal azide for click chemistry and a t-butyl ester as an acid-labile protecting group. The PEG2 spacer specifically provides hydrophilicity and flexibility, making it useful for orthogonal conjugation, probe development, and drug delivery.
Key Features and Benefits:
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Azide Group: Enables CuAAC and SPAAC click chemistry with alkynes.
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t-Butyl Ester: Provides acid-labile protection for controlled deprotection.
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PEG2 Spacer: Improves solubility and reduces steric hindrance.
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High Purity: Ensures reproducibility in conjugation workflows.
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Dual Functionality: Combines click-ready and protected groups for multifunctional synthesis.
Applications:
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Bioconjugation: Enables orthogonal attachment of biomolecules through azide ligation and amide coupling.
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Drug Delivery: PEGylated design enhances solubility and stability of conjugates.
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Probe Development: Builds multifunctional scaffolds for imaging or diagnostic tools.
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Synthetic Chemistry: Acts as an intermediate for advanced PEG-based constructs.
Storage and Handling:
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Storage: Store at –20 °C, tightly sealed and light-protected.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain ester and azide stability.
This product combines a bioorthogonal azide with acid-labile ester protection in a compact PEG framework, making it especially versatile for multifunctional bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
