Azido-SS-PEG2-acid
This product is a heterobifunctional PEG linker containing an azide group, a disulfide (SS) bond, a PEG2 spacer, and a terminal carboxylic acid. It specifically enables click chemistry, cleavable linkage, and amide coupling, offering solubility and multifunctionality.
Key Features and Benefits
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Azide Group: Reacts rapidly with alkynes via CuAAC or SPAAC click chemistry.
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Disulfide Bond: Provides cleavable linkage for reductive release under intracellular conditions.
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Carboxylic Acid: Couples efficiently with primary amines to form stable amide bonds.
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PEG2 Spacer: Enhances solubility with compact chain length.
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High Purity: Ensures reproducibility in bioconjugation and cleavable linker workflows.
Applications
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Bioconjugation: Links azide-modified and amine-containing biomolecules with a cleavable spacer.
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Drug Delivery: Enables controlled release of conjugated payloads under reductive environments.
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Probe Development: Builds cleavable probes for imaging and diagnostics.
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Chemical Biology: Supports cleavable linker strategies in cellular studies.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or disulfide reduction.
This product integrates azide click chemistry with a cleavable disulfide bond and carboxyl reactivity in a PEG2 scaffold, specifically offering controlled and versatile conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
