Azido-SS-PEG2-acid CAS:2144777-72-8 is a chemical compound that consists of a polyethylene glycol (PEG) chain with an azido functional group, a disulfide linker, and a carboxylic acid group at one end. Azido-SS-PEG2-acid is commonly used as a linker molecule for the modification of peptides and proteins.
The azido functional group in Azido-SS-PEG2-acid can undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with alkyne-functionalized molecules to form a stable triazole linkage between the two molecules. This reaction is commonly used in bioconjugation applications to attach small molecules, peptides, and proteins to each other or to surfaces.
The disulfide linker in Azido-SS-PEG2-acid can be used to introduce a reducible linkage between the target molecule and the PEG chain. This disulfide bond can be cleaved under reducing conditions, such as in the presence of a reducing agent like dithiothreitol (DTT), to release the modified target molecule.
The carboxylic acid group in Azido-SS-PEG2-acid can be used to facilitate the attachment of the linker molecule to a target molecule through amide bond formation. The PEG chain in Azido-SS-PEG2-acid can impart hydrophilicity and biocompatibility, making it a useful tool in the design of biomaterials.
Azido-SS-PEG2-acid is commonly used in the development of drug delivery systems, where it can be used to modify drug molecules, peptides, or proteins to increase their solubility, stability, and bioavailability. It can also be used to prepare bioconjugates for diagnostic and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
