Azido-PEG8-CH2CO2H
Azido-PEG8-CH2CO2H is a high-purity PEG linker with an azide for click chemistry and a carboxylic acid for orthogonal conjugation. The PEG8 spacer enhances solubility and flexibility, enabling efficient bioconjugation in aqueous and organic systems for drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
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Carboxylic Acid Group: Couples efficiently to primary amines via carbodiimide chemistry (e.g., EDC/NHS).
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PEG8 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal conjugation workflows.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Stepwise Bioconjugation: Sequentially attach azide and amine-reactive partners.
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Protein and Peptide Modification: Introduce azide handles for click chemistry while coupling acids to amines.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted delivery systems.
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Drug Delivery Systems: Create linkers for precise payload attachment and release.
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Diagnostic Probe Development: Build multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG8-CH2CO2H combines azide click reactivity with a carboxylic acid handle in a hydrophilic PEG8 spacer, providing a long, flexible linker for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
