Azido-PEG5-CH2CO2-tBu
Azido-PEG5-CH2CO2-tBu is a high-purity heterobifunctional PEG linker with an azide group for bioorthogonal click chemistry (CuAAC or SPAAC) and a t-butyl ester–protected carboxylic acid for orthogonal conjugation. The PEG5 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in aqueous and organic systems. The acid-labile t-butyl ester allows controlled deprotection for stepwise functionalization, making it ideal for precision linker design in drug delivery, diagnostics, and biomaterials.
Key Features and Benefits
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Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
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t-Butyl Ester Protection: Acid-labile, allowing selective deprotection for sequential coupling.
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PEG5 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal conjugation workflows.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Stepwise Bioconjugation: Sequentially attach azide and carboxylic acid partners.
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Protein and Peptide Modification: Introduce azide handles while reserving a protected acid for later use.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted delivery.
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Drug Delivery Systems: Build linkers for precise payload attachment and release.
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Diagnostic Probe Development: Create multifunctional imaging and sensing probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG5-CH2CO2-tBu combines azide click reactivity with acid-protected functionality in a hydrophilic PEG5 spacer, offering a longer, more flexible linker specifically for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
