Azido-PEG4-Val-Cit-PAB-OH
This product is a cleavable linker featuring an azide group for click chemistry, a PEG4 spacer, and a Val-Cit-PAB moiety for enzyme-sensitive drug release. This design combines bioorthogonal reactivity with controlled cleavage, making it especially effective in ADC development, drug delivery, and targeted bioconjugation.
Key Features and Benefits:
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Azide Group: Enables CuAAC or SPAAC click chemistry with alkynes.
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PEG4 Spacer: Enhances solubility and steric accessibility.
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Val-Cit-PAB Unit: Provides cathepsin-sensitive cleavage for controlled release.
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Dual Reactivity: Combines click chemistry with enzymatic release functionality.
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High Purity: Ensures reproducibility in sensitive drug design workflows.
Applications:
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ADC Development: Supports controlled drug release in antibody–drug conjugates.
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Drug Delivery: Provides enzyme-sensitive PEGylated linkers for targeted therapy.
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Probe Development: Builds bioorthogonal, cleavable imaging probes.
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Bioconjugation: Enables multifunctional strategies in advanced therapeutics.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF); avoid premature exposure to hydrolytic or enzymatic conditions.
This product integrates click-ready azide functionality with an enzyme-cleavable Val-Cit-PAB unit, making it an especially versatile linker for targeted drug delivery and ADC design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
