Azido-PEG4-Val-Cit-PAB-MMAE CAS:1869126-64-6 produced by AXISPHARM is a cleavable ADC linker for drug-linker conjugates of ADC using the anti-mitotic agent monomethyl auristatin E (MMAE, a microtubule protein inhibitor), linked via a cleavable linker Azido-PEG4-Val-Cit-PAB-O, which contains an azido-PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PABC linker, and an MMAE efficient The payload is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
