Azido-PEG3-Maleimide
This product is a heterobifunctional linker containing an azide group, a three-unit PEG spacer, and a maleimide group. The azide performs copper-catalyzed (CuAAC) or copper-free (SPAAC) click chemistry with alkynes, while the maleimide reacts selectively with thiols to form stable thioether bonds. The PEG3 spacer specifically improves solubility and reduces steric hindrance, making this reagent highly versatile for dual-functional bioconjugation.
Key Features and Benefits
-
Azide Group: Enables CuAAC or SPAAC click chemistry with alkyne partners.
-
Maleimide Group: Couples selectively with thiols to form thioether bonds.
-
PEG3 Spacer: Adds solubility, flexibility, and minimizes steric effects.
-
Dual Reactivity: Supports orthogonal conjugation strategies in one molecule.
-
High Purity: Produced to ≥95% purity for reliable performance.
Applications
-
Bioconjugation: Links azide-modified and thiol-containing biomolecules.
-
Protein and Antibody Labeling: Provides dual handles for multifunctional modification.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Functions as a modular linker in therapeutic conjugates.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, moisture-free container.
-
Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product integrates thiol-selective and azide-click reactivity in a short PEG scaffold, specifically offering flexibility for compact conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.