Azido-PEG3-Hydrazide
Azido-PEG3-Hydrazide is a high-purity heterobifunctional PEG linker featuring a terminal azide group for copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC) click chemistry and a hydrazide group for conjugation with aldehydes or ketones to form stable hydrazone bonds. The PEG3 spacer specifically improves hydrophilicity, increases solubility, and reduces steric hindrance, enabling efficient coupling in both aqueous and organic systems.
Key Features
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Azide group for highly selective click chemistry with alkynes
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Hydrazide group for efficient coupling with carbonyl groups (aldehydes/ketones)
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PEG3 spacer enhances solubility, flexibility, and reduces aggregation
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High chemical purity and stability
Applications
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Dual-functional conjugation strategies combining click chemistry and carbonyl coupling
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Protein, peptide, and antibody modification
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Nanoparticle and surface functionalization
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Drug delivery and targeted therapy
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Diagnostic probe and biosensor development
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product features an azide for click chemistry and a hydrazide for carbonyl coupling, with a PEG3 spacer specifically for improved solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
