Azido-PEG1-Val-Cit-PAB-OH
Azido-PEG1-Val-Cit-PAB-OH is a high-purity cleavable PEG linker with an azide for click chemistry, a cathepsin B–cleavable Val-Cit dipeptide, and a PAB spacer specifically for payload release. Its short PEG1 spacer especially enhances solubility and flexibility, ensuring stability in circulation and controlled intracellular release for ADCs, targeted therapeutics, and diagnostic probes.
Key Features and Benefits
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Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
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Val-Cit Cleavable Linker: Stable in systemic circulation, selectively cleaved by cathepsin B inside target cells.
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PAB Self-Immolative Spacer: Triggers rapid and complete payload release after enzymatic cleavage.
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PEG1 Spacer: Improves solubility, flexibility, and reaction efficiency.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Antibody–Drug Conjugates (ADCs): Link antibodies to drugs for targeted cancer therapy.
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Peptide–Drug Conjugates: Enable site-specific, enzyme-triggered payload release.
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Nanoparticle Functionalization: Add cleavable linkers for targeted drug delivery.
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Prodrug Development: Incorporate linkers that activate in disease-specific environments.
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Diagnostic Probe Development: Create targeted imaging agents with controlled release profiles.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
Azido-PEG1-Val-Cit-PAB-OH combines azide click chemistry with a cathepsin B–cleavable Val-Cit linker and a PAB spacer for rapid payload release, making it an especially versatile tool for ADCs, targeted therapeutics, and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
