ARV-825 CAS:1818885-28-7 is a PROTAC linked by ligands of Cereblon and BRD4. It is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, resulting in rapid, efficient and prolonged degradation of BRD4 and sustained downregulation of MYC. The effects of ARV-825 treatment were more pronounced on c-MYC levels and downstream cell proliferation and apoptosis induction in BL (Burkitt’s lymphoma) cell lines.
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