Aminooxyacetamide-PEG4-Propargyl
Aminooxyacetamide-PEG4-Propargyl is a high-purity heterobifunctional PEG linker featuring an aminooxy group for oxime ligation with aldehydes or ketones and a terminal alkyne for CuAAC click chemistry. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient and orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Aminooxyacetamide Group – Reacts selectively with aldehyde or ketone groups to form stable oxime bonds.
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Terminal Alkyne Group – Compatible with CuAAC click chemistry for rapid, high-yield bioconjugation.
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PEG4 Spacer – Improves water solubility and accessibility of reactive groups while minimizing steric interference.
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Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent and reproducible results.
Applications
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Dual-functional linker for orthogonal conjugation
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Protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) synthesis
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Multifunctional probe and diagnostic agent preparation
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to preserve reactivity
This product combines aldehyde/ketone-reactive aminooxy chemistry with alkyne-based click conjugation, linked by a PEG4 spacer for improved solubility and flexibility— especially ideal for precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.