Aminoethyl-SS-ethylalcohol
This product is a bifunctional linker featuring a terminal primary amine, a terminal hydroxyl group, and a central disulfide (–SS–) bond. It enables reversible conjugation strategies, specifically allowing controlled cleavage under reducing conditions while providing versatile handles for further derivatization.
Key Features and Benefits
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Primary Amine: Couples efficiently with carboxyls, NHS esters, and activated linkers.
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Hydroxyl Group: Offers an additional reactive handle for derivatization.
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Disulfide Bond: Provides a cleavable linkage under reducing conditions.
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Dual Reactivity: Combines amine and hydroxyl functionalities with reducible chemistry.
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High Purity: Ensures reproducible results in bioconjugation workflows.
Applications
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Bioconjugation: Links biomolecules with controlled release via disulfide reduction.
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Probe Development: Builds cleavable probes for imaging and diagnostics.
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Drug Delivery: Serves as a scaffold for reducible linkers in therapeutic conjugates.
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Material Science: Functionalizes polymers and nanoparticles with reversible chemistry.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid reducing environments before intended cleavage.
This product combines amine and hydroxyl groups with a reducible disulfide linkage, specifically offering a versatile scaffold for cleavable conjugation and reversible bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
