Amino-PEG6-t-butyl Ester (CAS: 1286281-32-0)
Amino-PEG6-t-butyl ester is a heterobifunctional PEG linker with an amino group at one end and a t-butyl-protected carboxyl group at the other. Its PEG6 spacer enhances water solubility and flexibility, making it ideal for bioconjugation and drug development applications.
Key Features:
- Functional Groups:
- Amino Group (-NH₂): Reacts with carboxylic acids, NHS esters, and carbonyl compounds.
- t-Butyl-Protected Carboxyl Group (-COOtBu): Can be deprotected under acidic conditions for further conjugation.
- PEG6 Spacer:
- Increases hydrophilicity and flexibility, reducing steric hindrance in conjugation reactions.
Applications:
- Bioconjugation: For synthesizing small-molecule conjugates and biomolecule linkers.
- Antibody-Drug Conjugates (ADCs): Improves solubility and pharmacokinetics of ADCs.
- PROTACs Development: Useful in designing targeted protein degradation compounds.
Handling and Storage:
- Molecular Formula: C₁₉H₃₉NO₈
- Molecular Weight: 409.51 g/mol
- Physical Form: Liquid
- Storage: Store at -20°C, protected from light and moisture.
This product is commonly used in medicinal chemistry and bioconjugation research due to its water-soluble and reactive structure.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
