Amino-PEG6-CH2CO2-t-butyl ester
This product is a high-purity PEG linker with a primary amine and a t-butyl ester-protected carboxylic acid. The PEG6 spacer improves solubility and flexibility, specifically enabling efficient stepwise bioconjugation.
Key Features and Benefits
- Primary Amine: Reacts readily with NHS esters, isocyanates, aldehydes, and other electrophiles.
- t-Butyl Ester-Protected Carboxylic Acid: Stable under neutral and basic conditions, easily deprotected under mild acidic conditions to reveal a reactive carboxylic acid.
- PEG6 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
- Heterobifunctional Design: Enables orthogonal and sequential modification strategies.
- High Purity: Supplied at >95% purity for reliable and reproducible results.
Applications
- Stepwise Bioconjugation: Protect the carboxylic acid for controlled timing of functionalization.
- Protein and Peptide Modification: Couple amines to biomolecules while reserving carboxyl reactivity for later steps.
- Nanoparticle and Surface Functionalization: Introduce primary amines for attachment to activated surfaces.
- Drug Delivery Systems: Incorporate protected acid handles for post-conjugation payload release strategies.
- Diagnostic and Imaging Probes: Create multifunctional probes with sequential modification capability.
Storage and Handling
- Storage: Store at –20 °C, dry, and protected from light.
- Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.
Amino-PEG6-CH2CO2-t-butyl ester combines a primary amine with a protected carboxylic acid in a hydrophilic PEG6 framework, providing flexibility for orthogonal bioconjugation specifically in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
