Amino-PEG5-CH2CO2-t-butyl Ester
This product is a high-purity, heterobifunctional PEG linker featuring a primary amine on one end and a t-butyl ester-protected carboxylic acid on the other. The PEG5 spacer improves hydrophilicity, reduces steric hindrance, and provides optimal spacing between functional groups, enabling efficient conjugation in both aqueous and organic systems. The t-butyl ester serves as an acid-labile protecting group, allowing selective deprotection for controlled activation of the carboxylic acid.
Key Features and Benefits:
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Dual Functional Groups: Primary amine for reaction with activated esters; t-butyl ester-protected acid for selective deprotection.
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PEG5 Spacer: Enhances solubility and flexibility while maintaining optimal reactivity.
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High Purity: Ensures reliable and reproducible coupling results.
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Orthogonal Reactivity: Supports stepwise and multi-functional conjugation strategies.
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Versatile Use: Suitable for small-molecule modification, polymer functionalization, and biomolecule labeling.
Applications:
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Bioconjugation: Create multifunctional molecules with precise control of functional group activation.
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Targeted Drug Delivery: Functionalize carriers for site-specific delivery systems.
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Surface Modification: Introduce reactive handles to nanoparticles, hydrogels, or biosensors.
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PEGylation: Enhance solubility and stability of bioactive compounds.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve reactivity; avoid strong acids or bases until deprotection is desired.
Amino-PEG5-CH2CO2-t-butyl ester is an effective heterobifunctional PEG linker that combines amine reactivity with a protected acid, enabling stepwise conjugation and versatile use in drug delivery, bioconjugation, and advanced material development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
