Amino-PEG4-CH2CO2-t-butyl ester
This product is a high-purity PEG linker with a primary amine for amide coupling and a t-butyl ester–protected acid for orthogonal conjugation. The PEG4 spacer enhances solubility, flexibility, and accessibility, enabling efficient bioconjugation in both aqueous and organic systems. The acid-labile t-butyl ester allows controlled deprotection for stepwise functionalization, making it especially suitable for drug delivery, diagnostics, and biomaterials.
Key Features and Benefits
-
Primary Amine: Reacts readily with activated esters or carboxylic acids.
-
t-Butyl Ester Protection: Allows selective deprotection for sequential functionalization.
-
PEG4 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
-
High Purity: Supplied at >95% purity for reproducibility and reliable results.
Applications
-
Stepwise bioconjugation with orthogonal reactivity.
-
Protein and peptide modification.
-
Nanoparticle and surface functionalization.
-
Targeted drug delivery systems.
-
Multifunctional diagnostic probe development.
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
This product combines amine reactivity with protected acid functionality specifically for orthogonal bioconjugation, delivering solubility and flexibility in multifunctional linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.