Amino-PEG4-CH2CO2-t-butyl ester
This product is a high-purity PEG linker with a primary amine for amide coupling and a t-butyl ester–protected acid for orthogonal conjugation. The PEG4 spacer enhances solubility, flexibility, and accessibility, enabling efficient bioconjugation in both aqueous and organic systems. The acid-labile t-butyl ester allows controlled deprotection for stepwise functionalization, making it especially suitable for drug delivery, diagnostics, and biomaterials.
Key Features and Benefits
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Primary Amine: Reacts readily with activated esters or carboxylic acids.
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t-Butyl Ester Protection: Allows selective deprotection for sequential functionalization.
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PEG4 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
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High Purity: Supplied at >95% purity for reproducibility and reliable results.
Applications
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Stepwise bioconjugation with orthogonal reactivity.
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Protein and peptide modification.
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Nanoparticle and surface functionalization.
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Targeted drug delivery systems.
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Multifunctional diagnostic probe development.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
This product combines amine reactivity with protected acid functionality specifically for orthogonal bioconjugation, delivering solubility and flexibility in multifunctional linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
