Amino-PEG36-t-butyl ester
This long-chain PEG36 reagent has a terminal amine and an acid-labile t-butyl ester. The PEG spacer improves solubility and flexibility, while the t-butyl ester allows controlled deprotection for orthogonal conjugation.
Key Features and Benefits:
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Amine Group: Reactive handle for coupling with carboxyls, NHS esters, and other electrophiles.
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t-Butyl Ester Protection: Acid-labile group for selective deprotection.
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PEG36 Spacer: Enhances water solubility, reduces aggregation, and provides long-chain spacing.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Versatile Reactivity: Compatible with aqueous and organic systems.
Applications:
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Bioconjugation: Site-specific attachment of proteins, peptides, and biomolecules.
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Drug Delivery: PEGylation linker to improve solubility and pharmacokinetic properties.
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Surface Modification: Functionalization of nanoparticles, hydrogels, and biosensors.
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Advanced Materials: PEGylation of polymers for biomedical and material science research.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve amine and ester integrity.
This product combines a reactive amine, acid-labile ester protection, and long PEG spacing, making it an especially versatile linker for advanced conjugation and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
