Amino-PEG36-CH2CO2-t-butyl ester
This high-purity PEG linker has a primary amine for amide coupling and a tert-butyl–protected carboxyl for mild acidic deprotection. Its long PEG36 spacer provides excellent solubility, flexibility, and low steric hindrance, specifically enabling efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Primary Amine – Reacts readily with activated esters (e.g., NHS) for stable amide bond formation.
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Tert-Butyl Ester Protection – Allows selective deprotection under mild acidic conditions to reveal a reactive carboxylic acid.
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PEG36 Spacer – Provides excellent solubility, flexibility, and reduces steric hindrance between conjugated moieties.
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Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable and reproducible results.
Applications
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Dual-functional linker for orthogonal conjugation strategies
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Protein, peptide, and small molecule modification
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Antibody–drug conjugate (ADC) linker chemistry
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Multifunctional imaging and diagnostic probe development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) and avoid prolonged exposure to moisture to maintain reactivity.
This product combines a primary amine for amide coupling with a tert-butyl–protected carboxyl for mild deprotection, linked by a long PEG36 spacer for superior solubility, flexibility, and low steric hindrance, especially ideal for precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
