Amino-PEG3-t-butyl ester
This product is a heterobifunctional PEG linker with a primary amine, a PEG3 spacer, and a tert-butyl ester. The amine reacts with carboxyls or NHS esters to form stable amides, while the tert-butyl ester protects a carboxyl group for controlled deprotection. The PEG3 chain improves solubility and reduces steric hindrance, making this reagent especially versatile for bioconjugation, probe development, and drug delivery.
Key Features and Benefits
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Amine Group: Couples efficiently with carboxyls or NHS esters.
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t-Butyl Ester: Provides a protected carboxyl for controlled deprotection.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility.
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Orthogonal Reactivity: Supports stepwise conjugation strategies.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links biomolecules with controlled functional group protection.
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Protein and Antibody Labeling: Enables orthogonal modification strategies.
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Drug Delivery: Functions as a modular linker for therapeutic design.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Remove t-butyl ester under mild acidic conditions; prepare fresh solutions before use.
This product combines a reactive amine, a protected ester, and PEG solubility in a compact design, specifically providing flexibility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
