Amino-PEG3-SS-acid is a versatile, bifunctional linker featuring an amine group, a polyethylene glycol (PEG) spacer, and a cleavable disulfide bond connected to a carboxylic acid moiety. The PEG segment improves solubility and biocompatibility, while the disulfide bond imparts redox sensitivity, enabling controlled release under reducing conditions.
This unique linker has gained significance in pharmaceutical research and development for its role in constructing targeted drug delivery systems, such as antibody-drug conjugates (ADCs). Amino-PEG3-SS-acid facilitates the attachment of cytotoxic agents to antibodies, ensuring enhanced tumor specificity and reduced systemic toxicity. Its cleavable nature allows for precise drug release in the targeted cells, optimizing therapeutic efficacy and minimizing adverse effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
