Amino-PEG3-CH2CO2-t-butyl Ester
Amino-PEG3-CH2CO2-t-butyl ester is a high-purity, heterobifunctional PEG linker featuring a primary amine group on one end and a t-butyl ester-protected carboxylic acid on the other. The PEG3 spacer enhances hydrophilicity, reduces steric hindrance, and provides optimal spacing between functional groups, enabling efficient conjugation in both aqueous and organic systems. The t-butyl ester serves as an acid-labile protecting group, allowing controlled carboxylic acid activation when needed.
Key Features and Benefits:
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Dual Functional Groups: Primary amine for coupling to activated esters; t-butyl ester-protected acid for selective deprotection.
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PEG3 Spacer: Improves solubility and flexibility while minimizing steric hindrance.
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High Purity: Ensures reproducible and reliable conjugation performance.
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Orthogonal Reactivity: Supports stepwise conjugation strategies.
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Versatile Use: Suitable for small-molecule modification, polymer functionalization, and biomolecule labeling.
Applications:
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Bioconjugation: Create multifunctional molecules with precise functional group placement.
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Targeted Drug Delivery: Functionalize carriers for site-specific delivery.
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Surface Modification: Introduce reactive handles to nanoparticles, hydrogels, or biosensors.
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PEGylation Strategies: Enhance solubility and stability of bioactive compounds.
Storage and Handling:
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Storage: Store at –20 °C, away from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to prevent premature hydrolysis; avoid strong bases and acids until deprotection is intended.
This product is an effective heterobifunctional PEG linker that combines amine reactivity with a protected acid functionality, making it highly valuable for stepwise, controlled conjugation in research and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
