Amino-PEG2-CH2CO2-t-butyl ester
Amino-PEG2-CH2CO2-t-butyl ester is a high-purity heterobifunctional PEG linker with a primary amine for amide bond formation and a t-butyl ester–protected carboxylic acid for orthogonal conjugation. The PEG2 spacer improves solubility, provides flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The acid-labile t-butyl ester allows controlled deprotection for stepwise functionalization, making it especially suitable for precision linker design in drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Primary Amine: Reacts readily with activated esters and other electrophiles.
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t-Butyl Ester–Protected Acid: Enables orthogonal conjugation via controlled acid deprotection.
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PEG2 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports sequential, orthogonal bioconjugation strategies.
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High Purity: Supplied at >95% purity for reliable, reproducible performance.
Applications
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Stepwise Bioconjugation: Sequentially couple amine and acid chemistries for multifunctional constructs.
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Protein and Peptide Modification: Add PEG linkers or functional handles with controlled reactivity.
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Nanoparticle Functionalization: Introduce orthogonal reactive groups for targeted applications.
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Drug Delivery Systems: Create stable linkers for precise payload attachment and release.
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Diagnostic Probes: Develop multifunctional imaging and sensing agents.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve ester integrity.
This product combines amine reactivity with an orthogonally protected acid in a hydrophilic PEG2 framework, enabling especially flexible, stepwise bioconjugation for therapeutics, diagnostics, and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
