Amino-PEG12-amine CAS: 361543-12-6 contains an amino functional group (-NH2) attached to one end of a PEG chain, which has a length of 12 units.
Amino-PEG12-amine has been extensively utilized in the development of novel drug delivery systems, such as PEGylation, where therapeutic agents, such as proteins and peptides, are attached to the PEG chain through covalent amide bonds. The resulting conjugates exhibit improved pharmacokinetics, reduced immunogenicity, and increased therapeutic efficacy compared to the free drugs. Furthermore, Amino-PEG12-amine can also be used to functionalize surfaces of nanoparticles, liposomes, and other carriers for drug delivery purposes, resulting in improved targeting, stability, and biocompatibility.
In addition to drug delivery applications, Amino-PEG12-amine has been employed as a linker in the synthesis of small molecule inhibitors, enabling the attachment of targeting moieties and improving their solubility and pharmacokinetics. Moreover, it has also been used as a coupling reagent in peptide and protein synthesis, allowing for the introduction of PEG chains to improve their properties.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
