Amino-PEG10-CH2CO2-t-butyl ester
This product is a high-purity PEG linker with a primary amine and a t-butyl-protected carboxylic acid. The PEG10 spacer specifically improves solubility, flexibility, and reduces steric hindrance. The amine couples with carboxylic acids or NHS esters, while the t-butyl ester can be deprotected under mild acid to yield a free acid for orthogonal bioconjugation and material modification.
Key Features and Benefits
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Primary Amine: Couples efficiently with carboxyl or NHS ester groups.
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t-Butyl Ester Protection: Allows controlled deprotection for sequential functionalization.
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PEG10 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
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Heterobifunctional Design: Supports orthogonal, site-specific modifications.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Protein, peptide, and small molecule conjugation.
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Surface and nanoparticle functionalization.
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PEGylation in drug delivery and diagnostics.
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Multi-step orthogonal labeling strategies.
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Advanced biomaterials development.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.
This product offers an amine for coupling and a protected acid for orthogonal conjugation, linked by a PEG10 spacer for especially excellent solubility and flexibility in bioconjugation and materials chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
