Alkyne-PEG4-hydrazide is a bifunctional linker molecule with an alkyne moiety at one end and a hydrazide group at the other, connected by a polyethylene glycol (PEG4) spacer. The alkyne group enables click chemistry reactions with azide-functionalized biomolecules, while the hydrazide group facilitates conjugation to aldehyde or ketone-containing molecules via the formation of stable hydrazone bonds. The PEG4 spacer provides enhanced water solubility, reduced steric hindrance, and increased flexibility to the linked biomolecules.
In pharmaceutical research and development, Alkyne-PEG4-hydrazide serves as an invaluable tool for creating bioconjugates, including drug-antibody conjugates, peptide-drug conjugates, and targeted drug delivery systems. The linker allows for site-specific and controlled conjugation of drug molecules to targeting moieties, such as antibodies or peptides, enabling precise delivery of therapeutics to disease-specific cells, while minimizing off-target effects and improving the overall safety profile of the drug candidate.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
