Ald-PEG4-TFP is a versatile and functionalized crosslinker widely utilized in pharmaceutical research and development. This bifunctional compound consists of an aldehyde (ALD) group, a polyethylene glycol spacer (PEG4), and a tetrafluorophenyl (TFP) ester group. The ALD moiety readily reacts with primary amines, forming stable imines, while the TFP ester group is designed to conjugate with amine-containing biomolecules, yielding stable amide bonds.
The PEG4 linker imparts enhanced solubility, reduced immunogenicity, and increased flexibility to the conjugated molecules. Ald-PEG4-TFP serves as an essential tool in bioconjugation, drug delivery systems, and targeted therapeutics development. Its applications span from antibody-drug conjugates and protein- or peptide-based therapeutics to hydrogel systems for drug release.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
